MethylScan® (Methylation Proteomics)
Histone methylation is crucial for proper programming of the genome during development, and misregulation of the methylation machinery can lead to diseased state including cancer. MethylScan® Service is a new PTMScan®Service offering that provides a unique and unparalleled strategy for global analysis of methyltransferase and demethylase activity on protein methylation. The Service utilizes antibodies with high affinity to mono-methylated arginine peptides for enrichment of mono-methylated peptides from protease-digested cell or tissue samples, followed by LC-MS/MS analysis for quantitative profiles of many hundreds of non-redundant mono-methylated sequences. Reagents for detection of di-methylated and tri-methylated peptides are currently in development. Please contact firstname.lastname@example.org for more information.
MethylScan® Workflow Diagram 0.6 MB
|Target||Antibody||Bead||Kit||Consenus Site||Cell or Tissue Type||Peptides Identified|
|Methylated-Arginine||8015||-||-||Me-R||Mouse Brain and Embryo||
1109|PDF XLS (results)