Product Pathways - Nuclear Receptor Signaling
RAI2 (D4W9P) Rabbit mAb #97857
|97857S||100 µl ( 10 western blots )||￥3,250.00 现货查询||购买询价|
|97857||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Species predicted to react based on 100% sequence homology: Mouse, Rat, Bovine, Pig,
Specificity / Sensitivity
RAI2 (D4W9P) Rabbit mAb recognizes endogenous levels of total RAI2 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg522 of human RAI2 protein.
Western blot analysis of extracts from various cell lines using RAI2 (D4W9P) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).
Retinoic acid-induced protein 2 (RAI2) is a 530 amino acid protein, encoded by the RAI2 gene on XP22.3 (1). RAI2 contains a central, proline-rich domain that is hypothesized to play a role in protein-protein interactions, and is expressed in a variety of embryonic and adult tissues (2). Beyond that, little is known about the biological functions of RAI2. Notably, a 2015 research study reported that suppressing RAI2 led to increased hematogenous dissemination of breast cancer cells to bone marrow, suggesting that RAI2 may function to negatively regulate tumor metastasis (3).
- Walpole, S.M. et al. (1999) Genomics 55, 275-83.
- Jonk, L.J. et al. (1994) Dev Biol 161, 604-14.
- Werner, S. et al. (2015) Cancer Discov 5, 506-19.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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