Cell Signaling Technology

Product Pathways - Nuclear Receptor Signaling

RAI2 (D4W9P) Rabbit mAb #97857

No. Size Price
97857S 100 µl ( 10 western blots ) ¥3,250.00 现货查询 购买询价 防伪查询
97857 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human, Endogenous 78 Rabbit IgG
IP 1:50

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IP=Immunoprecipitation,


Species predicted to react based on 100% sequence homology: Mouse, Rat, Bovine, Pig,

Specificity / Sensitivity

RAI2 (D4W9P) Rabbit mAb recognizes endogenous levels of total RAI2 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg522 of human RAI2 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using RAI2 (D4W9P) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).



Immunoprecipitation of RAI2 from BT-474 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is RAI2 (D4W9P) Rabbit mAb. Western blot analysis was performed using RAI2 (D4W9P) Rabbit mAb.


Retinoic acid-induced protein 2 (RAI2) is a 530 amino acid protein, encoded by the RAI2 gene on XP22.3 (1). RAI2 contains a central, proline-rich domain that is hypothesized to play a role in protein-protein interactions, and is expressed in a variety of embryonic and adult tissues (2). Beyond that, little is known about the biological functions of RAI2. Notably, a 2015 research study reported that suppressing RAI2 led to increased hematogenous dissemination of breast cancer cells to bone marrow, suggesting that RAI2 may function to negatively regulate tumor metastasis (3).

  1. Walpole, S.M. et al. (1999) Genomics 55, 275-83.
  2. Jonk, L.J. et al. (1994) Dev Biol 161, 604-14.
  3. Werner, S. et al. (2015) Cancer Discov 5, 506-19.

Application References

Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!


Companion Products

For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

XP is a registered trademark of Cell Signaling Technology, Inc.

Tween is a registered trademark of ICI Americas, Inc.

Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.

用户评论 --- 共 0


我要参与评论 :