Product Pathways - Metabolism
AHCYL1/IRBIT (D3A5G) Rabbit mAb #94248
adenosylhomocysteinase-like 1 AdoHcyase 2 AHCYL1 DC-expressed AHCY-like molecule DCAL dendritic cell expressed AHCY-like protein inositol 1.4.5-trisphosphate receptor-binding protein IRBIT PRO0233 Putative adenosylhomocysteinase 2 S-adenosyl homocysteine hydrolase homolog S-adenosyl-L-homocysteine hydrolase 2 S-adenosylhomocysteine hydrolase-like 1 S-adenosylhomocysteine hydrolase-like protein 1 SAHH2 XPVKONA
|94248S||100 µl ( 10 western blots )||￥3,100.00 现货查询||购买询价|
|94248||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Specificity / Sensitivity
AHCYL1/IRBIT (D3A5G) Rabbit mAb recognizes endogenous levels of total AHCYL1/IRBIT protein. This antibody does not cross-react with AHCYL2/IRBIT2 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu50 of human AHCYL1/IRBIT protein.
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) is a member of S-adenosylhomocysteine hydrolase family, which participates in the metabolism of S-adenosyl-L-homocysteine (1). Two Drosophila homologs of S-adenosylhomocysteine hydrolase-like proteins, dAhcyL1 and dAhcyL2, were identified as novel components of methionine metabolism (2). dAhcyL1 and dAhcyL2 function as dominant-negative regulators of S-adenosylhomocysteine hydrolase (2). Global down-regulation of both dAhcyL1 and dAhcyL2 extended life span (2). In addition, brain-specific down regulation of dAhcyL1 extended life span (2). AHCYL1 is also known as inositol 1,4,5-trisphosphate receptor (IP3R) binding protein released with IP3 (IRBIT) (1, 3). This protein binds to the endoplasmic reticulum calcium release channel IP3R and represses its acitivity (1, 3). As a multifunctional regulator, AHCYL1/IRBIT can also form a complex with and suppress the activity of ribonucleotide reductase, thereby influencing the balance of deoxynucleotide triphosphates essential for DNA replication and genomic integrity (4).
- Jeong, W. et al. (2012) PLoS One 7, e49204.
- Parkhitko, A.A. et al. (2016) Genes Dev 30, 1409-22.
- Kawaai, K. et al. (2015) Proc Natl Acad Sci U S A 112, 5515-20.
- Arnaoutov, A. and Dasso, M. (2014) Science 345, 1512-5.
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