Cell Signaling Technology

Product Pathways - PI3K / Akt Signaling

MAP4K3 (D1L4G) Rabbit mAb #92427

germinal center kinase-like kinase   Germinal center kinase-related protein kinase   GLK   M4K3   MAP4K3   MAPK/ERK kinase kinase kinase 3   MAPKKKK3   MEK kinase kinase 3   MEKKK 3   Mitogen-activated protein kinase kinase kinase kinase 3   RAB8IPL1  

No. Size Price
92427S 100 µl ( 10 western blots ) ¥3,250.00 现货查询 购买询价 防伪查询
92427 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Monkey, Endogenous 101 Rabbit IgG
IP 1:50

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IP=Immunoprecipitation,

Specificity / Sensitivity

MAP4K3 (D1L4G) Rabbit mAb recognizes endogenous levels of total MAP4K3 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu452 of human MAP4K3 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using MAP4K3 (D1L4G) Rabbit mAb.

Background

The mTORC1 kinase complex is a critical regulator of cell growth (1,2). Its activity is modulated by growth factors and nutrients including amino acids (1,2). MAP4K3 is a mediator between nutrient signal and mTORC1 (1). Research studies suggest that amino acid sufficiency leads to the phosphorylation of Ser170 on MAP4K3, which activates mTORC1 (3).

  1. Findlay, G.M. et al. (2007) Biochem J 403, 13-20.
  2. Sancak, Y. et al. (2008) Science 320, 1496-501.
  3. Yan, L. et al. (2010) Mol Cell 37, 633-42.

Application References

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Protocols

Companion Products


For Research Use Only. Not For Use In Diagnostic Procedures.

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