Cell Signaling Technology

Product Pathways - Lymphocyte Signaling

ICOS (D1K2T™) Rabbit mAb (IHC Specific) #89601

CD278   ICOS  

No. Size Price
89601S 100 µl ( 200 sections ) ¥3,250.00 现货查询 购买询价 防伪查询
89601 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
IHC-P 1:200 Human, Endogenous 25-40 Rabbit IgG
IHC-Bond 1:200

Species cross-reactivity is determined by western blot.

Applications Key: IHC-P=Immunohistochemistry (Paraffin), IHC-Bond=IHC-Leica® Bond™,

Specificity / Sensitivity

ICOS (D1K2T™) Rabbit mAb recognizes endogenous levels of total ICOS protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human ICOS protein.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human tonsil using ICOS (D1K2T™) Rabbit mAb.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human lymphoma using ICOS (D1K2T™) Rabbit mAb.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human colon carcinoma using ICOS (D1K2T™) Rabbit mAb.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human breast carcinoma using ICOS (D1K2T™) Rabbit mAb.

IHC-Leica Bond

IHC-Leica Bond

Immunohistochemical analysis of paraffin-embedded human colon adenocarcinoma using ICOS (D1K2T™) (IHC Specific) Rabbit mAb performed on the Leica® Bond™ Rx.

Background

ICOS (Inducible Co-Stimulator, CD278) is a member of the CD28 family that regulates T cell activity and immune responses (1). The ICOS protein contains an extracellular IgV like domain, a transmembrane domain, and an intracellular domain with a YMFM motif (1-2). ICOS is primarily expressed on activated CD4+ and CD8+ T cells (1). Upon binding to its ligand, ICOS potentiates the T cell response to antigen through activation of the PI3K signaling pathway (2). In addition to enhancing T cell activation and proliferation, ICOS plays an important role in the regulation of T follicular helper cells (4). Research studies suggest that ICOS is a potential therapeutic target, and could serve as a prognostic biomarker for neoplastic therapy involving CTLA-4 blockade (5-7).

  1. Hutloff, A. et al. (1999) Nature 397, 263-6.
  2. Coyle, A.J. et al. (2000) Immunity 13, 95-105.
  3. Fos, C. et al. (2008) J Immunol 181, 1969-77.
  4. Hutloff, A. (2015) Oncotarget 6, 21785-6.
  5. Kyi, C. and Postow, M.A. (2014) FEBS Lett 588, 368-76.
  6. Fan, X. et al. (2014) J Exp Med 211, 715-25.
  7. Ng Tang, D. et al. (2013) Cancer Immunol Res 1, 229-34.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

SignalStain is a trademark of Cell Signaling Technology, Inc.

D1K2T is a trademark of Cell Signaling Technology. Inc.

Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.

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