Product Pathways - Adhesion
MMP-2 (D2O4T) Rabbit mAb #87809
|87809S||100 µl ( 10 western blots )||￥3,100.00 现货查询||购买询价|
|87809||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Species predicted to react based on 100% sequence homology: Rat,
Specificity / Sensitivity
MMP-2 (D2O4T) Rabbit mAb recognizes endogenous levels of total MMP-2 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro117 of human MMP-2 protein.
Immunoprecipitation of MMP-2 protein from U87 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is MMP-2 (D2O4T) Rabbit mAb. Western blot analysis was performed using MMP-2 (D2O4T) Rabbit mAb.
The matrix metalloproteinases (MMPs) are a family of proteases that target many extracellular proteins including other proteases, growth factors, cell surface receptors, and adhesion molecules (1). Among the family members, MMP-2, MMP-3, MMP-7, and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis, and apoptosis (2-4). Research studies have shown that MMP activity correlates with cancer development (2). One mechanism of MMP regulation is transcriptional (5). Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full length protein (5).
- McCawley, L.J. and Matrisian, L.M. (2001) Curr Opin Cell Biol 13, 534-40.
- Coussens, L.M. et al. (2002) Science 295, 2387-92.
- Sternlicht, M.D. et al. (1999) Cell 98, 137-46.
- Vu, T.H. et al. (1998) Cell 93, 411-22.
- Nagase, H. et al. (1990) Biochemistry 29, 5783-9.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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