渲染靶标:SSR
Render Timestamp: 2025-01-05T10:34:38.738Z
Commit: 286c369131ceeedcf44c821941824d8d7e009e57
XML generation date: 2024-08-01 15:31:30.446
Product last modified at: 2024-05-30T07:09:57.327Z
1% for the Planet 标识
PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

Caspase-14 Antibody #8519

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Filter:
  • WB
Western Blotting Image 1: Caspase-14 Antibody
Western blot analysis of extracts from mouse and rat skin using Caspase-14 Antibody.
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Inquiry Info. # 8519

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Supporting Data

REACTIVITY H M R
SENSITIVITY Endogenous
MW (kDa) 28-30, 11
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 
  • M-Mouse 
  • R-Rat 

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

Caspase-14 Antibody recognizes endogenous levels of total caspase-14 protein and the p11 subunit of mature caspase-14.

Species Reactivity:

Human, Mouse, Rat

The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

Species predicted to react based on 100% sequence homology:

Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human caspase-14 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Caspases are a family of cysteine proteases that play an essential role in carrying out apoptosis. Caspase-14, also named MICE, is a unique member of the caspase family with restricted expression; it is found in embryonic tissues and adult skin (1,2). Caspase-14 is weakly processed into p18 and p11 subunits by caspase-8 (2). Caspase-14 may not play a role in apoptosis (2), but instead may regulate keratinocyte differentiation (3). Expression of caspase-14 may protect from psoriasis (4,5) and irradiation damage (6). Caspase-14 may also be responsible for proteolytic processing of filaggrin during terminal differentiation of keratinocytes (6).

Pathways

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For Research Use Only. Not For Use In Diagnostic Procedures.
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