Product Pathways - Lymphocyte Signaling
PD-L2 (D7U8C™) XP® Rabbit mAb #82723
|82723S||100 µl ( 10 western blots )||￥7,500.00 现货查询||购买询价|
|82723T||20 µl ( 2 western blots )||￥2,000.00 现货查询||购买询价|
|82723||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IHC-P=Immunohistochemistry (Paraffin),
Specificity / Sensitivity
PD-L2 (D7U8C) XP® Rabbit mAb recognizes endogenous levels of total PD-L2 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg168 of human PD-L2 protein.
Western blot analysis of HDLM-2 and Jurkat cell extracts using PD-L2 (D7U8C) XP® Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).
Immunohistochemical analysis of paraffin-embedded human tonsil using PD-L2 (D7U8C) XP® Rabbit mAb.
Immunohistochemical analysis of paraffin-embedded human mediastinal large B-cell lymphoma using PD-L2 (D7U8C) XP® Rabbit mAb.
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using PD-L2 (D7U8C) XP® Rabbit mAb.
Programmed cell death 1 ligand 2 (PD-L2, B7-DC, CD273) is a member of the B7 family of cell surface ligands that regulate T-cell activation and immune responses (1,2). PD-L2 binds the PD-1 transmembrane receptor and inhibits T-cell activation. PD-L2 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by activated dendritic cells, macrophages, and T-cells (1,3). Similar in structure to related B7 family members, PD-L2 protein contains extracellular IgV and IgC2 domains, a transmembrane domain, and a short, cytoplasmic region. Research studies demonstrate that PD-L2 is expressed in several tumor types, including lung cancer, renal cell carcinoma, melanoma, Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma (4-7).
- Latchman, Y. et al. (2001) Nat Immunol 2, 261-8.
- Tseng, S.Y. et al. (2001) J Exp Med 193, 839-46.
- Messal, N. et al. (2011) Mol Immunol 48, 2214-9.
- Kim, M.Y. et al. (2015) Lung Cancer 88, 24-33.
- Taube, J.M. et al. (2014) Clin Cancer Res 20, 5064-74.
- Green, M.R. et al. (2010) Blood 116, 3268-77.
- Ansell, S.M. et al. (2015) N Engl J Med 372, 311-9.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
- 12369 Nitrocellulose Sandwiches
- 12630 SignalFire™ Plus ECL Reagent
- 12757 SignalFire™ Elite ECL Reagent
- 13747 SignalSlide® PD-L1 IHC Controls
- 14166 Hematoxylin
- 14177 SignalStain® Mounting Medium
- 14747 SignalStain® EDTA Unmasking Solution (10X)
- 15019 Animal-Free Blocking Solution (5X)
- 5425 Normal Goat Serum
- 6883 SignalFire™ ECL Reagent
- 7074 Anti-rabbit IgG, HRP-linked Antibody
- 7727 Biotinylated Protein Ladder Detection Pack
- 8059 SignalStain® DAB Substrate Kit
- 8112 SignalStain® Antibody Diluent
- 8114 SignalStain® Boost IHC Detection Reagent (HRP, Rabbit)
- 9997 Tris Buffered Saline with Tween® 20 (TBST-10X)
- 9998 BSA
For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
XP is a registered trademark of Cell Signaling Technology, Inc.
SignalSlide is a registered trademark of Cell Signaling Technology, Inc.
SignalStain is a trademark of Cell Signaling Technology, Inc.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.
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