Product Pathways - Transcription Factors
BCL11A (D4E3P) Rabbit mAb #75432
|75432S||100 µl ( 10 western blots )||￥3,100.00 现货查询||购买询价|
|75432||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation,
Specificity / Sensitivity
BCL11A (D4E3P) Rabbit mAb recognizes endogenous levels of total BCL11A protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val247 of human BCL11A protein.
Immunoprecipiation of BCL11A from RPMI 8226 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is BCL11A (D4E3P) Rabbit mAb. Western blot analysis was performed using BCL11A (D4E3P) Rabbit mAb.
BCL11A is a zinc finger-containing transcriptional repressor that is important for normal hematopoiesis (1). Alternative splicing of the BCL11A transcript results in several isoforms of the protein (2). BCL11A is required for the early stages of B lineage commitment and mice lacking BCL11A fail to develop B cells (1). Mice deficient in BCL11A also fail to develop plasmacytoid dendritic cells (3). In addition, BCL11A regulates the switch from fetal to adult hemoglobin by repressing expression of fetal hemoglobin in adult erythroid cells (4). Since expression of fetal hemoglobin can decrease the severity of hemoglobin disorders in adults, BCL11A is a potential therapeutic target for these diseases (4). BCL11A was also recently identified as a component of the mammalian SWI/SNF complex (5). BCL11A is required for morphogenesis and terminal differentiation of dorsal spinal neurons (6).
- Liu, P. et al. (2003) Nat Immunol 4, 525-32.
- Liu, H. et al. (2006) Mol Cancer 5, 18.
- Ippolito, G.C. et al. (2014) Proc Natl Acad Sci U S A 111, E998-1006.
- Sankaran, V.G. et al. (2008) Science 322, 1839-42.
- Kadoch, C. et al. (2013) Nat Genet 45, 592-601.
- John, A. et al. (2012) Development 139, 1831-41.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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