Product Pathways - Lymphocyte Signaling
TNFRSF9/4-1BB Antibody #62634
4-1BB 4-1BB ligand receptor CD137 CD137 antigen CDw137 homolog of mouse 4-1BB ILA induced by lymphocyte activation (ILA) interleukin-activated receptor. homolog of mouse Ly63 MGC2172 receptor protein 4-1BB T cell antigen ILA T-cell antigen 4-1BB homolog T-cell antigen ILA TNFRSF9 TNR9 Tumor necrosis factor receptor superfamily member 9 tumor necrosis factor receptor superfamily. member 9
|62634S||100 µl ( 10 western blots )||￥3,100.00 现货查询||购买询价|
|62634||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting,
Specificity / Sensitivity
TNFRSF9/4-1BB Antibody recognizes endogenous levels of total TNFRSF9/4-1BB protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln128 of human TNFRSF9/4-1BB protein. Antibodies are purified by protein A and peptide affinity chromatography.
Western blot analysis of extracts from activated primary human CD8+ T cells and HDLM-2 cells using TNFRSF9/4-1BB Antibody.
Western blot analysis of extracts from COS-7 cells, mock transfected (-) or transfected with a construct expressing Myc-tagged full-length human TNFRSF9/4-1BB (hTNFRSF9/4-1BB-Myc; +), untreated (-) or treated (+) by PNGase F, using TNFRSF9/4-1BB Antibody (upper), Myc-Tag (9B11) Mouse mAb #2276 (middle), or β-Actin (D6A8) Rabbit mAb #8457 (lower).
TNFRSF9 is a member of the tumor necrosis factor receptor superfamily (1, 2). It is also called 4-1BB or CD137 (1, 2). TNFRSF9/4-1BB is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells (2-5) . The ligand TNFSF9/4-1BBL on antigen presenting cells binds to TNFRSF9/4-1BB and costimulates the activation of T cells (5). The binding of agonistic antibodies to TNFRSF9/4-1BB also leads to costimulation for T cell activation (5). Studies have shown the effectiveness of targeting TNFRSF9/4-1BB by its agonistic antibodies in cancer immunotherapy (6).
- Sun, Y. et al. (2002) Nat Med 8, 1405-13.
- Wilcox, R.A. et al. (2002) J Clin Invest 109, 651-9.
- Lin, W. et al. (2008) Blood 112, 699-707.
- Wilcox, R.A. et al. (2002) J Immunol 168, 4262-7.
- Melero, I. et al. (1997) Nat Med 3, 682-5.
- Yonezawa, A. et al. (2015) Clin Cancer Res 21, 3113-20.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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