Cell Signaling Technology

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CD63 (D4I1X) Rabbit mAb (IHC Specific) #55051

No. Size Price
55051S 100 µl ( 10 western blots ) ¥3,250.00 现货查询 购买询价 防伪查询
55051 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
IHC-P 1:400 Human, Endogenous Rabbit IgG

Species cross-reactivity is determined by western blot.

Applications Key: IHC-P=Immunohistochemistry (Paraffin),

Specificity / Sensitivity

CD63 (D4I1X) Rabbit mAb (IHC Specific) recognizes endogenous levels of total CD63 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant CD63 protein.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human colon carcinoma using CD63 (D4I1X) Rabbit mAb (IHC Specific).

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human melanoma using CD63 (D4I1X) Rabbit mAb (IHC Specific).

IHC-P (paraffin)

IHC-P (paraffin)

lung:

Immunohistochemical analysis of paraffin-embedded human lung carcinoma using CD63 (D4I1X) Rabbit mAb (IHC Specific).

IHC-P (paraffin)

IHC-P (paraffin)

lymph:

Immunohistochemical analysis of paraffin-embedded human Non-Hodgkin's Lymphoma using CD63 (D4I1X) Rabbit mAb (IHC Specific).

Background

CD63 belongs to the tetraspanin family, which is characterized by four transmembrane domains, one short extracellular domain (ECL1), and one long extracellular domain (ECL2) (1-3). Tetraspanins interact with a variety of cell surface proteins and intracellular signaling molecules in specialized tetraspanin enriched microdomains (TEMs) where they mediate a range of processes including adhesion, motility, membrane organization, and signal transduction (3). CD63, like other tetraspanins, is enriched in exosomes (4). It is also a component of Weibel-Palade bodies found in endothelial cells (5). Research studies demonstrate several functions of CD63 in different cell types including roles in mast cell degranulation, VEGF signaling in endothelial cells, recruitment of leukocytes to endothelial cells, and endosomal sorting during melanogenesis (6-9).

  1. Oren, R. et al. (1990) Mol Cell Biol 10, 4007-15.
  2. Levy, S. et al. (1991) J Biol Chem 266, 14597-602.
  3. Hemler, M.E. (2005) Nat Rev Mol Cell Biol 6, 801-11.
  4. Escola, J.M. et al. (1998) J Biol Chem 273, 20121-7.
  5. Vischer, U.M. and Wagner, D.D. (1993) Blood 82, 1184-91.
  6. Kraft, S. et al. (2013) J Immunol 191, 2871-8.
  7. Tugues, S. et al. (2013) J Biol Chem 288, 19060-71.
  8. Doyle, E.L. et al. (2011) Blood 118, 4265-73.
  9. van Niel, G. et al. (2011) Dev Cell 21, 708-21.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

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