Product Pathways - Autophagy Signaling
NBR1 (D2E6) Rabbit mAb (PE Conjugate) #54516
|54516S||100 µl ( 50 tests )||￥4,060.00 现货查询||购买询价|
|54516||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: F=Flow Cytometry,
Specificity / Sensitivity
NBR1 (D2E6) Rabbit mAb (PE Conjugate) recognizes endogenous levels of total NBR1 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys601 of human NBR1 protein.
This Cell Signaling Technology antibody is conjugated to phycoerythrin (PE) and tested in-house for direct flow cytometry analysis in human cells. This antibody is expected to exhibit the same species cross-reactivity as the unconjugated NBR1 (D2E6) Rabbit mAb #9891.
Next to BRCA1 gene 1 (NBR1) protein is known for its encoding gene proximity to the BRCA1 tumor suppressor gene (1,2). N-terminal Phox and Bem1p (PB1) domains of NBR1 mediate its interaction with muscle specific titin kinase (3,4) and scaffolding protein p62 (4). NBR1 plays a role in autophagy by facilitating the autophagosomal degradation of ubiquitinated proteins independently and also in concert with p62 (5,6).
- Campbell, I.G. et al. (1994) Hum Mol Genet 3, 589-94.
- Miki, Y. et al. (1994) Science 266, 66-71.
- Lange, S. et al. (2005) Science 308, 1599-603.
- Müller, S. et al. (2006) FEBS Lett 580, 341-4.
- Kirkin, V. et al. (2009) Mol Cell 33, 505-16.
- Lamark, T. et al. (2009) Cell Cycle 8, 1986-90.
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For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
XP is a registered trademark of Cell Signaling Technology, Inc.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.
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