Cell Signaling Technology

Product Pathways - Metabolism

SDH5 (D1S8D) Rabbit mAb #45849

C11orf79   FLJ20487   hSDH5   paraganglioma or familial glomus tumors 2   PGL2   SDH assembly factor 2   SDH5   SDHAF2   SDHF2   Succinate dehydrogenase assembly factor 2. mitochondrial   succinate dehydrogenase complex assembly factor 2   Succinate dehydrogenase subunit 5. mitochondrial  

No. Size Price
45849S 100 µl ( 10 western blots ) ¥3,250.00 现货查询 购买询价
45849 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse,Rat,Monkey, Endogenous 15 Rabbit IgG
IP 1:50

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IP=Immunoprecipitation,

Specificity / Sensitivity

SDH5 (D1S8D) Rabbit mAb recognizes endogenous levels of total SDH5 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala155 of human SDH5 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell lines using SDH5 (D1S8D) Rabbit mAb.

Background

Succinate dehydrogenase subunit 5 (SDH5, SDHAF2) is a subunit of the succinate dehydrogenase (SDH) protein complex responsible for the oxidation of succinate during the citric acid cycle. Mitochondrial SDH5 associates with the catalytic subunit of succinate dehydrogenase and is required for adding FAD cofactor to the SDH catalytic subunit (1). Mutations in the corresponding SDHAF2 gene are associated with hereditary head and neck paragangliomas, an autosomal disorder characterized by the development of tumors with increased penetrance over time (1). Additional research studies show that SDH5 is involved in the regulation of lung cancer metastasis mediated by the glycogen synthase kinase 3β and β-catenin signaling pathways (2).

  1. Hao, H.X. et al. (2009) Science 325, 1139-42.
  2. Liu, J. et al. (2013) J Biol Chem 288, 29965-73.

Application References

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For Research Use Only. Not For Use In Diagnostic Procedures.

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