Cell Signaling Technology

Product Pathways - Neuroscience

Neurofibromin 1 (D7R7D) Rabbit mAb #14623

No. Size Price
14623S 100 µl ( 10 western blots ) ¥3,250.00 现货查询 购买询价 防伪查询
14623 carrier free & custom formulation / quantityemail request
Applications Dilution Species-Reactivity Sensitivity MW (kDa) Isotype
W 1:1000 Human,Mouse,Rat,Monkey, Endogenous 320 Rabbit IgG
IP 1:50

Species cross-reactivity is determined by western blot.

Applications Key: W=Western Blotting, IP=Immunoprecipitation,

Specificity / Sensitivity

Neurofibromin 1 (D7R7D) Rabbit mAb recognizes endogenous levels of total neurofibromin 1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro360 of human neurofibromin 1 protein.

Western Blotting

Western Blotting

Western blot analysis of extracts from HeLa and A204 cells using Neurofibromin 1 (D7R7D) Rabbit mAb.


Neurofibromin is a Ras-specific GTPase activating protein (RasGAP), down-regulating Ras signaling (1). Studies have shown, that mutations in NF1 inhibit its activity, resulting in benign tumors such as neurofibromas, which may form along nerves throughout the body resulting in neurofibromatosis type 1 (NF1) (2). NF1 is one of the most common autosomal dominant diseases however it remains unclear how mutation of NF1 may lead to other features of NF1 (3). In addition, NF1 mutations occur in 5-10% of human sporadic malignancies such as glioblastomas, lung adenocarcinomas, melanomas, breast and ovarian cancers, and acute myeloid leukemias. Mutations in NF1 can cause resistance to therapies including chemotherapy and radiation therapy (3).

  1. Trovó-Marqui, A.B. and Tajara, E.H. (2006) Clin Genet 70, 1-13.
  2. Barker, D. et al. (1987) Science 236, 1100-2.
  3. Ratner, N. and Miller, S.J. (2015) Nat Rev Cancer 15, 290-301.

Application References

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