Product Pathways - Growth Factors/Cytokines
IL-6 (D5W4V) XP® Rabbit mAb (Mouse Specific) (PE Conjugate) #13797
|13797S||100 µl ( 50 tests )||￥4,264.00 现货查询||购买询价|
|13797||carrier free & custom formulation / quantity||email request|
Species cross-reactivity is determined by western blot.
Applications Key: F=Flow Cytometry,
Specificity / Sensitivity
IL-6 (D5W4V) XP® Rabbit mAb (Mouse Specific) (PE Conjugate) recognizes endogenous levels of total IL-6 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant mouse IL-6 protein.
This Cell Signaling Technology antibody is conjugated to phycoerythrin (PE) and tested in-house for direct flow cytometry analysis in mouse cells. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated IL-6 (D5W4V) XP® Rabbit mAb (Mouse Specific) #12912.
Acute phase response is induced by interleukin-6 (IL-6) produced by T cells, macrophages, fibroblasts, endothelial and other cells (1,2). IL-6 induces proliferation or differentiation in many cell types including B cells, thymocytes and T cells. IL-6, in concert with TGF-β, is important for developing Th17 responses. IL-6 binds to IL-6Rα and through this association induces gp130 homodimerization (1). gp130 homodimerization triggers the Jak/Stat cascade and the SHP-2/Erk MAP kinase cascade (1,3,4). IL-6 also forms a complex with an IL-6Rα splice variant that is nonmembrane-associated (3). The IL-6/soluble IL-6Rα complex can then activate the gp130 signaling pathway in cells that express gp130 but not IL-6Rα (3). Research studies have shown that IL-6, through increasing expression of proangiogenic VEGF, may also contribute to metastatic breast cancer (5).
- Heinrich, P.C. et al. (1998) Biochem J 334 ( Pt 2), 297-314.
- Heinrich, P.C. et al. (1998) Z Ernahrungswiss 37 Suppl 1, 43-9.
- Jones, S.A. (2005) J Immunol 175, 3463-8.
- Jenkins, B.J. et al. (2004) Mol Cell Biol 24, 1453-63.
- Hong, D.S. et al. (2007) Cancer 110, 1911-28.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
XP is a registered trademark of Cell Signaling Technology, Inc.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.
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